
El Foldit 's feed: Blog
The first round of results on designed fibronectin are in....
We have previously described the design problem of improving fibronectin and we chose to produce a design by BootsMcGraw. The results are in, but unfortunately the product did not show an improvement in stabi...lity. The bacteria made the protein just fine, but it was largely insoluble. This happ...
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Mostra'n més...We have previously described the design problem of improving fibronectin and we chose to produce a design by BootsMcGraw. The results are in, but unfortunately the product did not show an improvement in stabi...lity. The bacteria made the protein just fine, but it was largely insoluble. This happ...
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El Foldit 's feed: News
Fix Update
We're posting a small update today that has a few new fixes and features, including: Timeout: the connection timeout has been increased to address some of the connection issues players are experiencing. Exploration map: There is now a zoom slider in the explor...ation map. Exploration condition: The...
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Mostra'n més...We're posting a small update today that has a few new fixes and features, including: Timeout: the connection timeout has been increased to address some of the connection issues players are experiencing. Exploration map: There is now a zoom slider in the explor...ation map. Exploration condition: The...
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El Foldit 's feed: Blog
Pack the Holes and Fight Cancer!
As the quest to develop new ways of fighting cancer continues, methods such as prodrug therapy are promising but currently lack the ideal tools necessary for effective treatment. One such tool is a non-immunogenic enzyme that catalyzes ...the deamination of cytosine, converting it to uracil. There...
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Mostra'n més...As the quest to develop new ways of fighting cancer continues, methods such as prodrug therapy are promising but currently lack the ideal tools necessary for effective treatment. One such tool is a non-immunogenic enzyme that catalyzes ...the deamination of cytosine, converting it to uracil. There...
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El Foldit 's feed: Blog
Will this work? We'll see....
One of the most recent design puzzles posted is a human fibronectin structure (from PDB: 1FNF). It is an all-beta protein that is commonly used as a scaffold for making antibody mimetics. The reason for using fibronectin is that it do...es not contain the disulfides commonly found in antibodi...
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Mostra'n més...One of the most recent design puzzles posted is a human fibronectin structure (from PDB: 1FNF). It is an all-beta protein that is commonly used as a scaffold for making antibody mimetics. The reason for using fibronectin is that it do...es not contain the disulfides commonly found in antibodi...
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El Foldit 's feed: Blog
new puzzle: finding home
The new puzzle "finding home" features a homing endonuclease recognizing its target DNA sequence. Homing endonucleases are proteins involved in transfer and replication of DNA sequences, in most of the cases their own. They recognize specific si...tes in the genome and are able to cut them precisel...
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Mostra'n més...The new puzzle "finding home" features a homing endonuclease recognizing its target DNA sequence. Homing endonucleases are proteins involved in transfer and replication of DNA sequences, in most of the cases their own. They recognize specific si...tes in the genome and are able to cut them precisel...
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El Foldit 's feed: News
Nucleic Acids!
We're excited today to post our first puzzle that contains DNA: "Finding Home"! We hope you will enjoy playing with this new type of structure! Check the blog later for more information on this particular puzzle.
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We're excited today to post our first puzzle that contains DNA: "Finding Home"! We hope you will enjoy playing with this new type of structure! Check the blog later for more information on this particular puzzle.
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El Foldit 's feed: Blog
Selection Mode Feedback
A couple months back, we released an update that allowed you to try out a new interface that we have been working on that was based upon selecting portions of the protein and perform actions on that selection. (Review of that update can be found ...at http://fold.it/portal/node/986573). We're inter...
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Mostra'n més...A couple months back, we released an update that allowed you to try out a new interface that we have been working on that was based upon selecting portions of the protein and perform actions on that selection. (Review of that update can be found ...at http://fold.it/portal/node/986573). We're inter...
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El Foldit 's feed: News
Scripting Developer Preview!
We've posted a new developer preview of recipe scripting! This update contains some other changes as well; they can be found in the release notes. Read the FAQ for instructions on trying the developer preview; please log any problems in t...he feedback tracker under developer preview.
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Mostra'n més...We've posted a new developer preview of recipe scripting! This update contains some other changes as well; they can be found in the release notes. Read the FAQ for instructions on trying the developer preview; please log any problems in t...he feedback tracker under developer preview.
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El Foldit 's feed: News
New Update!
We've posted a small new update to address some cases from the feedback tracker: - Pressing tab on a segment with the info panel up will close the info panel. - There is a checkbox for a dark background in the advanced view options. - This should fix the... problem where some scores were not re...
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Mostra'n més...We've posted a small new update to address some cases from the feedback tracker: - Pressing tab on a segment with the info panel up will close the info panel. - There is a checkbox for a dark background in the advanced view options. - This should fix the... problem where some scores were not re...
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El Foldit 's feed: News
Mini-CASP 3 deadline extended!
As we were hoping when we posted puzzle 199, the solved structure for Mini-CASP 3 that was supposed to be deposited tomorrow has been pushed back until November! This means that we will be able to post more blind Mini-CASP 3 puzzles (usi...ng Rosetta@home and Foldit predictions) in the next few w...
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Mostra'n més...As we were hoping when we posted puzzle 199, the solved structure for Mini-CASP 3 that was supposed to be deposited tomorrow has been pushed back until November! This means that we will be able to post more blind Mini-CASP 3 puzzles (usi...ng Rosetta@home and Foldit predictions) in the next few w...
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El Foldit 's feed: Blog
Exploration Puzzle 1
We're introducing a new puzzle today. It's also a new type of puzzle: one where you have to explore far from the starting structure. You've had a preview of this in the exploration map, and this map (Exploration Map in the Social tab) will be an i...mportant tool for these new puzzles. Explorat...
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Mostra'n més...We're introducing a new puzzle today. It's also a new type of puzzle: one where you have to explore far from the starting structure. You've had a preview of this in the exploration map, and this map (Exploration Map in the Social tab) will be an i...mportant tool for these new puzzles. Explorat...
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El Foldit 's feed: News
Puzzles!
We've posted two new beginner puzzles, and now the puzzles page and the top players block on the right side of the page should be working again!
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We've posted two new beginner puzzles, and now the puzzles page and the top players block on the right side of the page should be working again!
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El Foldit 's feed: News
New Puzzle
There's a new puzzle up: http://fold.it/portal/node/986792 You can read more about this one in the blog!
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There's a new puzzle up: http://fold.it/portal/node/986792 You can read more about this one in the blog!
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El Foldit 's feed: News
Upgrade
We're still having a few issues from the upgrade last week. Keep letting us know of any you find in the feedback tracker and we'll work on getting them fixed soon!
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We're still having a few issues from the upgrade last week. Keep letting us know of any you find in the feedback tracker and we'll work on getting them fixed soon!
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El Foldit 's feed: Blog
Cover the Ligand
As environmental impact becomes an increasing concern for chemical manufacturing, the idea of using enzymes in environmentally friendly conditions to catalyze chemical transformations instead of traditional chemistry is becoming increasingly impor...tant. Unfortunately, naturally occurring e...
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Mostra'n més...As environmental impact becomes an increasing concern for chemical manufacturing, the idea of using enzymes in environmentally friendly conditions to catalyze chemical transformations instead of traditional chemistry is becoming increasingly impor...tant. Unfortunately, naturally occurring e...
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